Trifluoroacetic acid → HCID 58137748, compound

HRID 2189454Notes

Reaction equation

HRID 2189454 reaction equation
C(OC([NH:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:19]3[CH:20]=[CH:21][N:22]=[C:23]([C:24]([O:26][CH3:27])=[O:25])[C:18]3=[N:17][N:16]=2)=[CH:11][CH:10]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:19]3[CH:20]=[CH:21][N:22]=[C:23]([C:24]([O:26][CH3:27])=[O:25])[C:18]3=[N:17][N:16]=2)=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58137741HCID 58137741, compound

Product 1

HCID 58137748HCID 58137748, compoundYield 99.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of methyl 3-(4-(tert-butoxycarbonylamino)phenyl)-[1,2,4]triazolo[4,3-a]pyrazine-8-carboxylate (61D) (130 mg, 0.35 mmol) in CH2Cl2 (1 mL) was added TFA (1 L). The resulting mixture was stirred at room temperature for 2 h, and then concentrated in vacuo. The obtained residue was stripped with CH2Cl2 and dried in high vacuum to yield the title compound as brown oil (94 mg). HPLC/MS (Method D): retention time=0.39 min, [M+H]+=270.5.

Workup

  1. concentrationconcentrated in vacuo
  2. customdried in high vacuum

Sources & evidence

ORD record
ord-8bb60625a7794d75bd8e307de0ce4e44
Source dataset
uspto-grants-2012_12
Patent number
US08324241B2

Reaction notes

Loading…