反应详情

温度

80 °C

2-Iodoxybenzoic acid (74) (804 mg, 2.87 mmol, Aldrich) was added to a solution of (3-(trifluoromethyl)isoxazol-5-yl)methanol (73) (300 mg, 1.44 mmol) in ethyl acetate (3 ml) at room temperature and stirred at 80° C. for 4 hours. After cooling to 0° C., insoluble materials were filtered off and the filtrate was concentrated in vacuo to give a crude product of 3-(trifluoromethyl)isoxazole-5-carbaldehyde (75) (270 mg, 57) as a pale-yellow solid.

1. temperatureAfter cooling to 0° C.
2. filtrationinsoluble materials were filtered off
3. concentrationthe filtrate was concentrated in vacuo