Triethylamine → HCID 86639129, compound

HRID 2189925Notes

Reaction equation

HRID 2189925 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:8]([C:9](=[O:14])[C@@H:10]([O:12][CH3:13])[CH3:11])[N:7]=[C:6]([C:15]2[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:16]=2[F:22])[S:5]1.[N:29]#[C:30]Br.C(N(CC)CC)C>ClCCl>[F:22][C:16]1[CH:17]=[CH:18][C:19]([F:21])=[CH:20][C:15]=1[C:6]1[S:5][C:4]([CH2:3][CH2:2][NH:1][C:30]#[N:29])([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[N:8]([C:9](=[O:14])[C@@H:10]([O:12][CH3:13])[CH3:11])[N:7]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 10476Cyanogen BromideHCID 67214531HCID 67214531, compound

Product 1

HCID 86639129HCID 86639129, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (2S)-1-(2-(2-aminoethyl)-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazol-3(2H)-yl)-2-methoxypropan-1-one (34.5 mg, 0.0721 mmol) and cyanogen bromide (9.9 mg, 0.0938 mmol) in dichloromethane (1 mL) was slowly added triethylamine (25.5 mg, 0.252 mmol). After stirring at room temperature for 1 hour, the mixture was concentrated under reduced pressure to provide the crude product that was used without further purification.

Workup

  1. concentrationthe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-811e4a05c3f3489986c7d1cd74b2afb5
Source dataset
uspto-grants-2012_12
Patent number
US08324257B2

Reaction notes

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