反应详情

To a solution of 4-(4-fluoro-phenyl)-4-[(S)-1-(4-fluoro-phenyl)-ethylcarbamoyl]-piperidine-1-carboxylic acid tert-butyl ester (735 mg, 1.653 mmol) in dichloromethane (8 mL) at 0° C. was added slowly trifluoroacetic acid (1.78 mL, 23.148 mmol) and stirring continued for 12 h at room temperature. The solvent was removed under reduced pressure. Toluene was added to the residue and evaporated under reduced pressure which was repeated two times. The residue was dried under high vacuum to yield 970 mg 4-(4-fluoro-phenyl)-piperidine-4-carboxylic acid [(S)-1-(4-fluoro-phenyl)-ethyl]-amide; compound with trifluoro-acetic acid. MS ISP (m/e): 345.3 [(M+H)+].

1. customThe solvent was removed under reduced pressure
2. additionToluene was added to the residue
3. customevaporated under reduced pressure which
4. customThe residue was dried under high vacuum