HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2189975Generated: October 26, 2026
Thionyl Chloride → Methyl 6-(chlorocarbonyl)nicotinate
https://huagongshe.com/reaction/2189975
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5-(Methoxycarbonyl)pyridine-2-carboxylic acid | HCID 314992 | — |
| Product | Methyl 6-(chlorocarbonyl)nicotinate | HCID 20707173 | — |
Reaction Steps
A mixture of pyridine-2,5-dicarboxylic acid 5-methyl ester (150 mg, 0.828 mmol) and thionyl chloride (1 mL) was heated at 80° C. for 5 h. The thionyl chloride was evaporated under reduced pressure, the residue was dried in high vacuum and used crude for the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08324250B2 |
|---|
| Source dataset | uspto-grants-2012_12 |
|---|
| ORD ID | ord-8857c10206db4311a11b0e99d107839e |
|---|
| Source note | uspto-grants-2012_12 |
|---|
