Hydrochloric Acid → HCID 59527902, compound

HRID 2189976Notes

Reaction equation

HRID 2189976 reaction equation
C[O:2][C:3](=[O:16])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:14][N:13]=[C:12]([CH3:15])[N:11]=2)=[N:6][CH:5]=1.[OH-].[K+].Cl>CO>[CH3:15][C:12]1[N:11]=[C:10]([C:7]2[CH:8]=[CH:9][C:4]([C:3]([OH:16])=[O:2])=[CH:5][N:6]=2)[O:14][N:13]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 66674612HCID 66674612, compound

Product 1

HCID 59527902HCID 59527902, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
70 °C

Procedure

To a solution of 6-(3-methyl-[1,2,4]oxadiazol-5-yl)-nicotinic acid methyl ester (54 mg, 0.246 mmol) in methanol (5 mL) was added an aqueous solution of KOH (3M, 0.49 mL, 1.48 mmol) and the mixture was heated at 70° C. for 12 h. The reaction mixture was neutralized under ice cooling with 2M HCl solution. The solvents were evaporated under reduced pressure, co-evaporated three times with toluene and dried under high vacuum. The acid was used crude for the next reaction. MS ISN (m/e): 204.2 [(M−H)−].

Workup

  1. customThe solvents were evaporated under reduced pressure
  2. customdried under high vacuum
  3. customfor the next reaction

Sources & evidence

ORD record
ord-f0cb1446e5f849a8ba6fcf8d2d9dff20
Source dataset
uspto-grants-2012_12
Patent number
US08324250B2

Reaction notes

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