反应详情

A solution of (5R)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one (5.00 g) and 1,6-dibromohexane (9.26 ml) in DMF (50 ml) at 0° under nitrogen was treated in three equal portions with sodium hydride (60% dispersion in mineral oil, 963 mg). The mixture was stirred at 0° for 30 min and then at 20° for a further 2.5 h. Phosphate buffer solution (pH 6.5, 50 ml) and water (150 ml) were added and the mixture was extracted with diethyl ether (2×150 ml). The combined extracts were washed with water (2×150 ml) and were dried (Na2SO4). The solvent was evaporated in vacuo and the residue was purified by flash chromatography on silica gel. Elution with MeOH-dichloromethane (1:4) gave the title compound (7.10 g). LCMS RT=3.52 min, ES+ve 412 (MH)+, 414 (MH)+.

1. waitat 20° for a further 2.5 h
2. extractionthe mixture was extracted with diethyl ether (2×150 ml)
3. washThe combined extracts were washed with water (2×150 ml)
4. dry with materialwere dried (Na2SO4)
5. customThe solvent was evaporated in vacuo
6. customthe residue was purified by flash chromatography on silica gel
7. washElution with MeOH-dichloromethane (1:4)