Ethyl 5-(3-chloro-4-fluorophenyl)-4-(3-cyano-5-fluorophenyl)furan-2-carboxylate → Ethyl 5-(3-chlorophenyl)-4-(3-cyano-5-fluorophenyl)furan-2-carboxylate

HRID 2190121Notes

Reaction equation

HRID 2190121 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[O:13][C:12]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:11][C:10]=2[C:19]2[CH:24]=[C:23]([F:25])[CH:22]=[C:21]([C:26]#[N:27])[CH:20]=2)[CH:5]=[CH:6][C:7]=1F.BrC1C=C(C(OCC)=O)OC=1C1C=CC=C(Cl)C=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[O:13][C:12]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:11][C:10]=2[C:19]2[CH:24]=[C:23]([F:25])[CH:22]=[C:21]([C:26]#[N:27])[CH:20]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 58064770Ethyl 5-(3-chloro-4-fluorophenyl)-4-(3-cyano-5-fluorophenyl)furan-2-carboxylateHCID 58064772Ethyl 4-bromo-5-(3-chlorophenyl)furan-2-carboxylate

Product 1

HCID 58064792Ethyl 5-(3-chlorophenyl)-4-(3-cyano-5-fluorophenyl)furan-2-carboxylate

Procedure

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 15A starting with the compound from Example 5A. 111 mg (52% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-db6aa10679fb4b0786ec0dbb7c804b78
Source dataset
uspto-grants-2012_12
Patent number
US08324268B2

Reaction notes

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