Ethyl 5-(3-chloro-4-fluorophenyl)-4-(3-cyano-5-fluorophenyl)furan-2-carboxylate → Ethyl 4-(3-cyano-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylate
Reaction equation
Cl[C:2]1[CH:3]=[C:4]([C:9]2[O:13][C:12]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:11][C:10]=2[C:19]2[CH:24]=[C:23]([F:25])[CH:22]=[C:21]([C:26]#[N:27])[CH:20]=2)[CH:5]=[CH:6][C:7]=1F.BrC1C=C(C(OCC)=O)OC=1C1C=CC=C([C:40]#[N:41])C=1>>[C:26]([C:21]1[CH:20]=[C:19]([C:10]2[CH:11]=[C:12]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[O:13][C:9]=2[C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([C:40]#[N:41])[CH:3]=2)[CH:24]=[C:23]([F:25])[CH:22]=1)#[N:27]Participants
3
Procedure
The synthesis of the title compound takes place in analogy to the synthesis of the compound from Example 15A starting with the compound from Example 8A. 190 mg (56% of theory) of the title compound are obtained.
Sources & evidence
- ORD record
- ord-06389bf1d6e24b28a7210b5b6ff189a1
- Source dataset
- uspto-grants-2012_12
- Patent number
- US08324268B2
Reaction notes
Loading…