反应详情

温度

50 °C

760 mg (2.10 mmol) of the compound from Example 14A are provided in 20 ml of dioxane, and 20 ml of a 2N aqueous lithium hydroxide solution are added at room temperature. The mixture is stirred at 50° C. for two hours and subsequently concentrated. A 1N aqueous HCl solution is then added until an acidic pH is established, the mixture is extracted with dichloromethane and the organic phase is dried over magnesium sulfate, filtered and concentrated. 401 mg (57% of theory) of the title compound are obtained.

1. concentrationsubsequently concentrated
2. additionA 1N aqueous HCl solution is then added until an acidic pH
3. extractionthe mixture is extracted with dichloromethane
4. dry with materialthe organic phase is dried over magnesium sulfate
5. filtrationfiltered
6. concentrationconcentrated