4-{[4-Bromo-5-(3-chlorophenyl)furan-2-yl]carbonyl}piperazin-2-one → 4-{[5-Bromo-4-(3-chlorophenyl)furan-2-yl]carbonyl}piperazin-2-one

HRID 2190129Notes

Reaction equation

HRID 2190129 reaction equation
BrC1C=C(C([N:16]2[CH2:21][CH2:20][NH:19][C:18](=[O:22])[CH2:17]2)=O)OC=1C1C=CC=C(Cl)C=1.[Br:23][C:24]1[O:28][C:27]([C:29]([OH:31])=O)=[CH:26][C:25]=1[C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([Cl:38])[CH:33]=1>>[Br:23][C:24]1[O:28][C:27]([C:29]([N:16]2[CH2:21][CH2:20][NH:19][C:18](=[O:22])[CH2:17]2)=[O:31])=[CH:26][C:25]=1[C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([Cl:38])[CH:33]=1

Participants

3

Reactant 2

HCID 580647644-{[4-Bromo-5-(3-chlorophenyl)furan-2-yl]carbonyl}piperazin-2-oneHCID 580648025-Bromo-4-(3-chlorophenyl)furan-2-carboxylic acid

Product 1

HCID 580647804-{[5-Bromo-4-(3-chlorophenyl)furan-2-yl]carbonyl}piperazin-2-one

Procedure

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 27A starting with the compound from Example 22A. 48.0 mg (79% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-c968acfb4bae494e8655befc1d8781c9
Source dataset
uspto-grants-2012_12
Patent number
US08324268B2

Reaction notes

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