3-[3-(3-Chloro-5-fluorophenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)furan-2-yl]benzenecarbonitrile → [5-(3-Chloro-4-fluorophenyl)-4-(3-chloro-5-fluorophenyl)furan-2-yl](1,3-thiazolidin-3-yl)methanone

HRID 2190133Notes

Reaction equation

HRID 2190133 reaction equation
ClC1C=C(C2C=C(C([N:16]3[CH2:20][CH2:19][S:18][CH2:17]3)=O)OC=2C2C=C(C#N)C=CC=2)C=C(F)C=1.[Cl:29][C:30]1[CH:31]=[C:32]([C:37]2[O:41][C:40]([C:42]([OH:44])=O)=[CH:39][C:38]=2[C:45]2[CH:50]=[C:49]([F:51])[CH:48]=[C:47]([Cl:52])[CH:46]=2)[CH:33]=[CH:34][C:35]=1[F:36]>>[Cl:29][C:30]1[CH:31]=[C:32]([C:37]2[O:41][C:40]([C:42]([N:16]3[CH2:20][CH2:19][S:18][CH2:17]3)=[O:44])=[CH:39][C:38]=2[C:45]2[CH:50]=[C:49]([F:51])[CH:48]=[C:47]([Cl:52])[CH:46]=2)[CH:33]=[CH:34][C:35]=1[F:36]

Participants

3

Reactant 2

HCID 468323003-[3-(3-Chloro-5-fluorophenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)furan-2-yl]benzenecarbonitrileHCID 580647965-(3-Chloro-4-fluorophenyl)-4-(3-chloro-5-fluorophenyl)furan-2-carboxylic acid

Product 1

HCID 46832583[5-(3-Chloro-4-fluorophenyl)-4-(3-chloro-5-fluorophenyl)furan-2-yl](1,3-thiazolidin-3-yl)methanone

Procedure

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 1 starting with the compound from Example 21A. 144 mg (48% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-fa1ac8fe87ea48ca9d4c3e0baf7b36ed
Source dataset
uspto-grants-2012_12
Patent number
US08324268B2

Reaction notes

Loading…