4-(3-Chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylic acid → HCID 46832880, compound

HRID 2190141Notes

Reaction equation

HRID 2190141 reaction equation
ClC1C=C(C2C=C(C([N:22]3C[CH2:26][NH:25][C:24](=[O:28])[CH2:23]3)=O)OC=2C2C=CC(F)=CC=2)C=CC=1.[Cl:29][C:30]1[CH:31]=[C:32]([C:37]2[CH:38]=[C:39]([C:50]([OH:52])=O)[O:40][C:41]=2[C:42]2[CH:47]=[CH:46][CH:45]=[C:44]([C:48]#[N:49])[CH:43]=2)[CH:33]=[C:34]([F:36])[CH:35]=1>>[Cl:29][C:30]1[CH:31]=[C:32]([C:37]2[CH:38]=[C:39]([C:50]([N:22]3[CH2:23][C:24](=[O:28])[NH:25][CH2:26]3)=[O:52])[O:40][C:41]=2[C:42]2[CH:43]=[C:44]([C:48]#[N:49])[CH:45]=[CH:46][CH:47]=2)[CH:33]=[C:34]([F:36])[CH:35]=1

Participants

3

Reactant 2

HCID 580647984-(3-Chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylic acidHCID 580648004-{[4-(3-Chlorophenyl)-5-(4-fluorophenyl)furan-2-yl]carbonyl}piperazin-2-one

Product 1

HCID 46832880HCID 46832880, compound

Procedure

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 6 starting with the compound from Example 20A and the compound from Example 35A. 1.1 equivalents of the compound from Example 35A are used. 42.0 mg (70% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-4bc2efda5e0e4918bca35a2688892892
Source dataset
uspto-grants-2012_12
Patent number
US08324268B2

Reaction notes

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