4-{[4-Bromo-5-(3-chlorophenyl)furan-2-yl]carbonyl}piperazin-2-one → 4-{[5-(3-Chlorophenyl)-4-(3,5-dimethylphenyl)furan-2-yl]carbonyl}piperazin-2-one

HRID 2190143Notes

Reaction equation

HRID 2190143 reaction equation
ClC1C=C(C2C=C(C(N3CCNC(=O)C3)=O)O[C:12]=2[C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([CH3:19])[CH:14]=2)C=CC=1.Br[C:30]1[CH:31]=[C:32]([C:42]([N:44]2[CH2:49][CH2:48][NH:47][C:46](=[O:50])[CH2:45]2)=[O:43])[O:33][C:34]=1[C:35]1[CH:40]=[CH:39][CH:38]=[C:37]([Cl:41])[CH:36]=1>>[Cl:41][C:37]1[CH:36]=[C:35]([C:34]2[O:33][C:32]([C:42]([N:44]3[CH2:49][CH2:48][NH:47][C:46](=[O:50])[CH2:45]3)=[O:43])=[CH:31][C:30]=2[C:17]2[CH:16]=[C:15]([CH3:19])[CH:14]=[C:13]([CH3:12])[CH:18]=2)[CH:40]=[CH:39][CH:38]=1

Participants

3

Reactant 2

HCID 580647644-{[4-Bromo-5-(3-chlorophenyl)furan-2-yl]carbonyl}piperazin-2-oneHCID 580647794-{[4-(3-Chlorophenyl)-5-(3-methylphenyl)furan-2-yl]carbonyl}piperazin-2-one

Product 1

HCID 468331834-{[5-(3-Chlorophenyl)-4-(3,5-dimethylphenyl)furan-2-yl]carbonyl}piperazin-2-one

Procedure

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 18 starting with the compound from Example 27A. 15.0 mg (28% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-a784189c24264ee3a46f809d57a91f2a
Source dataset
uspto-grants-2012_12
Patent number
US08324268B2

Reaction notes

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