3-{2-(3-Chloro-4-fluorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]furan-3-yl}-5-fluorobenzenecarbonitrile → 3-{2-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]furan-3-yl}-5-fluorobenzenecarbonitrile

HRID 2190146Notes

Reaction equation

HRID 2190146 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[O:10][C:11]([C:23]([N:25]3[CH2:29][C:28](=[O:30])[NH:27][CH2:26]3)=[O:24])=[CH:12][C:13]=2[C:14]2[CH:15]=[C:16]([C:21]#[N:22])[CH:17]=[C:18]([F:20])[CH:19]=2)[CH:5]=[CH:6][C:7]=1F.ClC1C=C(C2OC(C(OCC)=O)=CC=2C2C=C(F)C=C(C#N)C=2)C=CC=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[O:10][C:11]([C:23]([N:25]3[CH2:29][C:28](=[O:30])[NH:27][CH2:26]3)=[O:24])=[CH:12][C:13]=2[C:14]2[CH:15]=[C:16]([C:21]#[N:22])[CH:17]=[C:18]([F:20])[CH:19]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 580647863-{2-(3-Chloro-4-fluorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]furan-3-yl}-5-fluorobenzenecarbonitrileHCID 58064792Ethyl 5-(3-chlorophenyl)-4-(3-cyano-5-fluorophenyl)furan-2-carboxylate

Product 1

HCID 468334843-{2-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]furan-3-yl}-5-fluorobenzenecarbonitrile

Procedure

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 31 starting with the compound from Example 16A. 29.9 mg (49% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-6a48b52fcbdf40d9b055fce716345d0b
Source dataset
uspto-grants-2012_12
Patent number
US08324268B2

Reaction notes

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