HRID2190194

反应详情

EQUATION

反应方程式

HRID 2190194 的结构方程式

CONDITIONS

反应条件

温度
150 °C

PROCEDURE

实验过程

To 5-iodo-N-methyl-6-(methylsulfonamido)-2-(p-tolyl)furo[2,3-b]pyridine-3-carboxamide (150 mg, 0.309 mmol) was added 1-(2-bromoethyl)-2-chlorobenzene (678 mg, 3.09 mmol) and CESIUM CARBONATE (101 mg, 0.309 mmol) was heated at 150° C. μwave 10 min. LCMS showed 1:1 SM/Prod and 1:2 styrene/Br. Added CESIUM CARBONATE (101 mg, 0.309 mmol) and heated additional 10 min at 150° C. μwave. Added water and extracted with EtOAc. Conc. on vac. Added ACN/water and filtered with 0.45 μPTFE filter

WORKUP

后处理

  1. extractionAdded water and extracted with EtOAc
  2. filtrationAdded ACN/water and filtered with 0.45 μPTFE
  3. filtrationfilter