HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2190194Generated: November 1, 2026
Cesium carbonate → 6-(N-(2-chlorophenethyl)methylsulfonamido)-5-iodo-N-methyl-2-(p-tolyl)furo[2,3-b]pyridine-3-carboxamide
https://huagongshe.com/reaction/2190194
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 1-(2-Bromoethyl)-2-chlorobenzene | HCID 2756963 | — |
| Reactant | 5-iodo-N-methyl-6-(methylsulfonamido)-2-p-tolylfuro[2,3-b]pyridine-3-carboxamide | HCID 58052356 | — |
| Product | 6-(N-(2-chlorophenethyl)methylsulfonamido)-5-iodo-N-methyl-2-(p-tolyl)furo[2,3-b]pyridine-3-carboxamide | HCID 58052442 | — |
Reaction Steps
To 5-iodo-N-methyl-6-(methylsulfonamido)-2-(p-tolyl)furo[2,3-b]pyridine-3-carboxamide (150 mg, 0.309 mmol) was added 1-(2-bromoethyl)-2-chlorobenzene (678 mg, 3.09 mmol) and CESIUM CARBONATE (101 mg, 0.309 mmol) was heated at 150° C. μwave 10 min. LCMS showed 1:1 SM/Prod and 1:2 styrene/Br. Added CESIUM CARBONATE (101 mg, 0.309 mmol) and heated additional 10 min at 150° C. μwave. Added water and extracted with EtOAc. Conc. on vac. Added ACN/water and filtered with 0.45 μPTFE filter
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08324239B2 |
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| Source dataset | uspto-grants-2012_12 |
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| ORD ID | ord-e8961f81035d48b08f4bf9c1f3b18d25 |
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| Source note | uspto-grants-2012_12 |
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