HRID2190199

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

结构：CCOC(=O)C(CCCCN(c1nc2oc(-c3ccc(C)cc3)c(C(=O)NC)c2cc1C1CC1)S(C)(=O)=O)S(C)(=O)=O

HCID58052450

未命名化合物

PRODUCTS

生成物

结构：CNC(=O)c1c(-c2ccc(C)cc2)oc2nc(N(CCCCC(C(=O)O)S(C)(=O)=O)S(C)(=O)=O)c(C3CC3)cc12

HCID58052553

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

To ethyl 6-(N-(5-cyclopropyl-3-(methylcarbamoyl)-2-(p-tolyl)furo[2,3-b]pyridin-6-yl)methylsulfonamido)-2-(methylsulfonyl)hexanoate was added 1 mL 50% NaOH and 3 mL EtOH. Stirred at RT ON Removed organic solvent on vac. Added 10 mL EtOAc. Added 20 mL conc. NH4OH and 5 mL 1N HCl and extracted with EtOAc. Washed with brine. Dried over Na2SO4, and conc. on vac. To give 6-(N-(5-cyclopropyl-3-(methylcarbamoyl)-2-(p-tolyl)furo[2,3-b]pyridin-6-yl)methylsulfonamido)-2-(methylsulfonyl)hexanoic acid.

WORKUP

后处理

customON Removed organic solvent on vac
additionAdded 10 mL EtOAc
additionAdded 20 mL conc. NH4OH and 5 mL 1N HCl
extractionextracted with EtOAc
washWashed with brine
dry with materialDried over Na2SO4

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1546c0fd626240f49324010cc1c4f5da
来源数据集: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08324239B2
来源说明: uspto-grants-2012_12

反应 SMILES

[CH:1]1([C:4]2[CH:5]=[C:6]3[C:31]([C:32](=[O:35])[NH:33][CH3:34])=[C:30]([C:36]4[CH:41]=[CH:40][C:39]([CH3:42])=[CH:38][CH:37]=4)[O:29][C:7]3=[N:8][C:9]=2[N:10]([CH2:15][CH2:16][CH2:17][CH2:18][CH:19]([S:25]([CH3:28])(=[O:27])=[O:26])[C:20]([O:22]CC)=[O:21])[S:11]([CH3:14])(=[O:13])=[O:12])[CH2:3][CH2:2]1.[OH-].[Na+]>CCO>[CH:1]1([C:4]2[CH:5]=[C:6]3[C:31]([C:32](=[O:35])[NH:33][CH3:34])=[C:30]([C:36]4[CH:41]=[CH:40][C:39]([CH3:42])=[CH:38][CH:37]=4)[O:29][C:7]3=[N:8][C:9]=2[N:10]([CH2:15][CH2:16][CH2:17][CH2:18][CH:19]([S:25]([CH3:28])(=[O:27])=[O:26])[C:20]([OH:22])=[O:21])[S:11]([CH3:14])(=[O:12])=[O:13])[CH2:2][CH2:3]1