HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 6-(N-(5-cyclopropyl-3-(methylcarbamoyl)-2-(p-tolyl)furo[2,3-b]pyridin-6-yl)methylsulfonamido)-2-(methylsulfonyl)hexanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | ethyl 6-(N-(5-cyclopropyl-3-(methylcarbamoyl)-2-(p-tolyl)furo[2,3-b]pyridin-6-yl)methylsulfonamido)-2-(methylsulfonyl)hexanoate | HCID 58052450 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-(N-(5-cyclopropyl-3-(methylcarbamoyl)-2-(p-tolyl)furo[2,3-b]pyridin-6-yl)methylsulfonamido)-2-(methylsulfonyl)hexanoic acid | HCID 58052553 | — |
Reaction Steps
To ethyl 6-(N-(5-cyclopropyl-3-(methylcarbamoyl)-2-(p-tolyl)furo[2,3-b]pyridin-6-yl)methylsulfonamido)-2-(methylsulfonyl)hexanoate was added 1 mL 50% NaOH and 3 mL EtOH. Stirred at RT ON Removed organic solvent on vac. Added 10 mL EtOAc. Added 20 mL conc. NH4OH and 5 mL 1N HCl and extracted with EtOAc. Washed with brine. Dried over Na2SO4, and conc. on vac. To give 6-(N-(5-cyclopropyl-3-(methylcarbamoyl)-2-(p-tolyl)furo[2,3-b]pyridin-6-yl)methylsulfonamido)-2-(methylsulfonyl)hexanoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324239B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-1546c0fd626240f49324010cc1c4f5da |
| Source note | uspto-grants-2012_12 |