HRID2190200

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8868

Ethyl acetoacetate

C6H10O3

结构：CNC(=O)c1c(-c2ccc(C)cc2)oc2nc(N(CCCCBr)S(C)(=O)=O)c(C3CC3)cc12

HCID54575876

未命名化合物

结构：CNC(=O)c1c(-c2ccc(C)cc2)oc2nc(N(CCCCC(C(=O)O)S(C)(=O)=O)S(C)(=O)=O)c(C3CC3)cc12

HCID58052553

未命名化合物

PRODUCTS

生成物

$结构：CNC(=O)c1c(-c2ccc(C)cc2)oc2nc(N(CCCC/C(C(=O)O)=C(\C)O)S(C)(=O)=O)c(C3CC3)cc12$

HCID58052471

未命名化合物

PROCEDURE

实验过程

Prepared similarly to Example 46 6-(N-(5-cyclopropyl-3-(methylcarbamoyl)-2-(p-tolyl)furo[2,3-b]pyridin-6-yl)methylsulfonamido)-2-(methylsulfonyl)hexanoic acid, by using ethyl 3-oxobutanoate in the alkylation with 6-(N-(4-bromobutyl)methylsulfonamido)-5-cyclopropyl-N-methyl-2-(p-tolyl)furo[2,3-b]pyridine-3-carboxamide, followed by hydrolysis.

WORKUP

后处理

customfollowed by hydrolysis

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-873dca5fa48547718fed0011a3216158
来源数据集: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08324239B2
来源说明: uspto-grants-2012_12

反应 SMILES

[CH:1]1([C:4]2[CH:5]=[C:6]3[C:29]([C:30](=[O:33])[NH:31][CH3:32])=[C:28]([C:34]4[CH:39]=[CH:38][C:37]([CH3:40])=[CH:36][CH:35]=4)[O:27][C:7]3=[N:8][C:9]=2[N:10]([CH2:15][CH2:16][CH2:17][CH2:18][CH:19](S(C)(=O)=O)[C:20]([OH:22])=[O:21])[S:11]([CH3:14])(=[O:13])=[O:12])[CH2:3][CH2:2]1.[O:41]=[C:42](C)[CH2:43]C(OCC)=O.BrCCCCN(C1N=C2OC(C3C=CC(C)=CC=3)=C(C(NC)=O)C2=CC=1C1CC1)S(C)(=O)=O>>[CH:1]1([C:4]2[CH:5]=[C:6]3[C:29]([C:30](=[O:33])[NH:31][CH3:32])=[C:28]([C:34]4[CH:35]=[CH:36][C:37]([CH3:40])=[CH:38][CH:39]=4)[O:27][C:7]3=[N:8][C:9]=2[N:10]([CH2:15][CH2:16][CH2:17][CH2:18]/[C:19](=[C:42](/[OH:41])\[CH3:43])/[C:20]([OH:22])=[O:21])[S:11]([CH3:14])(=[O:13])=[O:12])[CH2:3][CH2:2]1