反应详情

A solution of 2-(5-chloro-1,2,4-thiadiazol-3-yl)pyridine in 2 M ammonia in EtOH (10 ml) was heated overnight at 70° C. Volatiles were removed by concentration under reduced pressure. Purification by chromatography on silica (eluted with 0->10% MeOH/CH2Cl2+0->1% NH4OH) gave 3-(pyridin-2-yl)-1,2,4-thiadiazol-5-amine.

1. customVolatiles were removed by concentration under reduced pressure
2. customPurification by chromatography on silica (eluted with 0->10% MeOH/CH2Cl2+0->1% NH4OH)