HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-(Pyridin-2-yl)-1,2,4-thiadiazol-5-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 2-(5-Chloro-[1,2,4]thiadiazol-3-yl)-pyridine | HCID 46318465 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(Pyridin-2-yl)-1,2,4-thiadiazol-5-amine | HCID 21688995 | — |
Reaction Steps
A solution of 2-(5-chloro-1,2,4-thiadiazol-3-yl)pyridine in 2 M ammonia in EtOH (10 ml) was heated overnight at 70° C. Volatiles were removed by concentration under reduced pressure. Purification by chromatography on silica (eluted with 0->10% MeOH/CH2Cl2+0->1% NH4OH) gave 3-(pyridin-2-yl)-1,2,4-thiadiazol-5-amine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324396B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-0cc53435479649bb8fc0290cc97b7da6 |
| Source note | uspto-grants-2012_12 |