Sodium Bicarbonate → HCID 86628121, compound

HRID 2190317Notes

Reaction equation

HRID 2190317 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH:14][C:15]([CH3:18])([CH3:17])[CH3:16])(=[O:13])=[O:12])=[CH:7][CH:6]=1)=O.[NH2:19][C:20]([NH2:22])=[S:21].C([O-])(O)=O.[Na+]>CCO>[NH2:22][C:20]1[S:21][CH:2]=[C:3]([C:5]2[CH:10]=[CH:9][C:8]([S:11]([NH:14][C:15]([CH3:18])([CH3:17])[CH3:16])(=[O:13])=[O:12])=[CH:7][CH:6]=2)[N:19]=1

Participants

5

Reactant 3

HCID 516892Sodium BicarbonateHCID 2723790ThioureaHCID 57586391HCID 57586391, compound

Product 1

HCID 86628121HCID 86628121, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
70 °C

Procedure

To a solution of 4-(2-bromoacetyl)-N-tert-butylbenzenesulfonamide (8.71 g, 26.1 mmol) in EtOH (45 mL) was added thiourea (2.38 g, 31.3 mmol). The reaction mixture was heated to 70° C. for 15 h and poured into an aqueous solution of NaHCO3. The mixture was stirred for 30 min. The precipitate that formed was collected by filtration, washed with water, and dried under high vacuum to give 4-(2-aminothiazol-4-yl)-N-tert-butylbenzenesulfonamide.

Workup

  1. customThe precipitate that formed
  2. filtrationwas collected by filtration
  3. washwashed with water
  4. customdried under high vacuum

Sources & evidence

ORD record
ord-437b19af47b745359f5ff044cc689e20
Source dataset
uspto-grants-2012_12
Patent number
US08324396B2

Reaction notes

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