反应详情

温度

0 °C

150 mg (1.17 mmol, 1 eq) of 2-cyclohexylethanol were diluted in 4 mL of DCM, 214 μL (1.52 mmol, 1.3 eq) of triethylamine were added. The mixture was cooled to 0° C. and 100 μL (1.29 mmol, 1.1 eq) of mesyl chloride were added. The mixture was stirred for 15 min at 0° C. then water was added. The aqueous phase was extracted with dichloromethane. The organic phase was washed with water, brine, dried over MgSO4, filtered and concentrated in vacuo. The crude product (241 mg) was used directly for synthesis of 2. TLC: Rf: 0.48 (eluant: Heptane/EtOAc: 1/1).

1. extractionThe aqueous phase was extracted with dichloromethane
2. washThe organic phase was washed with water, brine
3. dry with materialdried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated in vacuo
6. customThe crude product (241 mg) was used directly for synthesis of 2