反应详情

温度

60 °C

To a solution of ethyl 3-(3-(5-chloro-4-(4-(methylsulfonamido)phenyl)thiazol-2-yl)-1-(3,3-diphenylpropyl)ureido)benzoate 73 (0.366 g, 0.531 mmol) in MeOH (20 mL) was added lithium hydroxide hydrate (0.440 g, 10.5 mmol). The reaction mixture was heated to 60° C. After 3 h, the reaction mixture was partially concentrated, neutralized with 1 M HCl, and diluted with EtOAc. The organic phase was washed with brine (1×), dried over MgSO4, filtered, and concentrated to give 3-(((5-chloro-4-(4-((methylsulfonyl)amino)phenyl)-1,3-thiazol-2-yl)carbamoyl)(3,3-diphenylpropyl)amino)benzoic acid 74. Mass spectrum, calculated for C33H29ClN4O5S2 660.1; found 661.1 (M++1).

1. concentrationthe reaction mixture was partially concentrated
2. additiondiluted with EtOAc
3. washThe organic phase was washed with brine (1×)
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated