反应详情

To a solution of methyl 4-chloro-3-(1-cyano-1-methylethyl)benzoate (8.0 g, 34 mmol) in tetrahydrofuran (30 mL) were added lithium hydroxide•monohydrate (2.13 g, 51 mmol), methanol (100 mL) and water (5 mL), and the mixture was stirred at room temperature for 4 hr. The solvent was evaporated under reduced pressure, and the residue was diluted with water (200 mL). The mixture was adjusted to pH 3 by slowly adding 1N hydrochloric acid. The resulting white precipitate was collected by filtration, washed with water, and dried to give the title compound (7.40 g, 99%) as a white powder.

1. customThe solvent was evaporated under reduced pressure
2. additionthe residue was diluted with water (200 mL)
3. additionby slowly adding 1N hydrochloric acid
4. filtrationThe resulting white precipitate was collected by filtration
5. washwashed with water
6. customdried