反应详情

6-Chloro-N-(3-fluoro-5-iodo-phenyl)-nicotinamide was prepared from 3-fluoro-5-iodo aniline and 6-chloronicotinoyl chloride following a procedure similar to the one described in the synthesis of 6-chloro-N-(4-iodo-3-methyl-phenyl)-nicotinamide, above. The product was isolated after suspension in small volume of CH2Cl2, filtration and then a wash with hexanes. HRMS m/z calcd for C12H7N2OClFI [M+H]+: 376.9349. Found: 376.9348

1. customThe product was isolated after suspension
2. filtrationin small volume of CH2Cl2, filtration
3. washa wash with hexanes