HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-5-iodoaniline → 6-Chloro-N-(3-fluoro-5-iodo-phenyl)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-5-iodoaniline | HCID 2758986 | — |
| Reactant | 6-Chloronicotinoyl Chloride | HCID 2782165 | — |
| Reactant | 6-chloro-N-(4-iodo-3-methyl-phenyl)-nicotinamide | HCID 59318138 | — |
| Product | 6-Chloro-N-(3-fluoro-5-iodo-phenyl)-nicotinamide | HCID 59317969 | — |
Reaction Steps
6-Chloro-N-(3-fluoro-5-iodo-phenyl)-nicotinamide was prepared from 3-fluoro-5-iodo aniline and 6-chloronicotinoyl chloride following a procedure similar to the one described in the synthesis of 6-chloro-N-(4-iodo-3-methyl-phenyl)-nicotinamide, above. The product was isolated after suspension in small volume of CH2Cl2, filtration and then a wash with hexanes. HRMS m/z calcd for C12H7N2OClFI [M+H]+: 376.9349. Found: 376.9348
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324385B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-8e9cf803e2674684a5f981ee6724681d |
| Source note | uspto-grants-2012_12 |