Aniline → HCID 5213538, compound

HRID 2190523Notes

Reaction equation

HRID 2190523 reaction equation
NC1C=CC=CC=1.ClC1C=CC(C(Cl)=O)=CN=1.[Cl:18][C:19]1[CH:35]=[CH:34][C:22]([C:23]([NH:25][C:26]2[CH:31]=[CH:30][C:29](I)=[C:28](C)[CH:27]=2)=[O:24])=[CH:21][N:20]=1>>[Cl:18][C:19]1[CH:35]=[CH:34][C:22]([C:23]([NH:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[O:24])=[CH:21][N:20]=1

Participants

4

Reactant 3

HCID 6115AnilineHCID 27821656-Chloronicotinoyl ChlorideHCID 593181386-chloro-N-(4-iodo-3-methyl-phenyl)-nicotinamide

Product 1

HCID 5213538HCID 5213538, compound

Procedure

6-Chloro-N-phenyl-nicotinamide was prepared from aniline and 6-chloronicotinoyl chloride following a procedure similar to the one described in the synthesis of 6-chloro-N-(4-iodo-3-methyl-phenyl)-nicotinamide, above. The product was isolated after precipitation out of small volume of CH2Cl2 with hexanes. HRMS m/z calcd for C12H9N2OCl [M+H]+: 233.0476. Found: 233.0476

Workup

  1. customThe product was isolated
  2. customafter precipitation out of small volume of CH2Cl2 with hexanes

Sources & evidence

ORD record
ord-c4516ecf6f7e499c8c42169157b9c56a
Source dataset
uspto-grants-2012_12
Patent number
US08324385B2

Reaction notes

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