2-Fluoro-4-iodoaniline → HCID 59318151, compound

HRID 2190531Notes

Reaction equation

HRID 2190531 reaction equation
[F:1][C:2]1[CH:8]=[C:7]([I:9])[CH:6]=[CH:5][C:3]=1[NH2:4].[Cl:10][C:11]1[CH:19]=[CH:18][C:14]([C:15](Cl)=[O:16])=[CH:13][N:12]=1.ClC1C=CC(C(NC2C=CC(I)=C(C)C=2)=O)=CN=1>>[Cl:10][C:11]1[CH:19]=[CH:18][C:14]([C:15]([NH:4][C:3]2[CH:5]=[CH:6][C:7]([I:9])=[CH:8][C:2]=2[F:1])=[O:16])=[CH:13][N:12]=1

Participants

4

Reactant 3

HCID 1856942-Fluoro-4-iodoanilineHCID 27821656-Chloronicotinoyl ChlorideHCID 593181386-chloro-N-(4-iodo-3-methyl-phenyl)-nicotinamide

Product 1

HCID 59318151HCID 59318151, compound

Procedure

6-Chloro-N-(2-fluoro-4-iodo-phenyl)-nicotinamide was prepared from 2-fluoro-4-iodo aniline and 6-chloronicotinoyl chloride following a procedure similar to the one described in the synthesis of 6-chloro-N-(4-iodo-3-methyl-phenyl)-nicotinamide, above. The product was isolated after precipitation out of a small volume of CH2Cl2 with hexanes. HRMS m/z calcd for C12H7N2OFClI [M+H]+: 376.9349. Found: 376.9349.

Workup

  1. customThe product was isolated
  2. customafter precipitation out of a small volume of CH2Cl2 with hexanes

Sources & evidence

ORD record
ord-32ff8a3418b04fba9f27113181b3ec09
Source dataset
uspto-grants-2012_12
Patent number
US08324385B2

Reaction notes

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