3-tert-Butylaniline → 4-Bromo-N-(3-tert-butyl-phenyl)-2-fluoro-benzamide

HRID 2190538Notes

Reaction equation

HRID 2190538 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([NH2:11])[CH:8]=[CH:9][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[Br:12][C:13]1[CH:21]=[CH:20][C:16]([C:17](O)=[O:18])=[C:15]([F:22])[CH:14]=1.BrC1C=CC(C(NC2C=CC=C(C(C)(C)C)C=2)=O)=CC=1F>>[Br:12][C:13]1[CH:21]=[CH:20][C:16]([C:17]([NH:11][C:7]2[CH:8]=[CH:9][CH:10]=[C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])[CH:6]=2)=[O:18])=[C:15]([F:22])[CH:14]=1

Participants

4

Reactant 3

HCID 793343-tert-ButylanilineHCID 3026814-Bromo-2-fluorobenzoic acidHCID 593181654-Bromo-N-(3-tert-butyl-phenyl)-3-fluoro-benzamide

Product 1

HCID 593179964-Bromo-N-(3-tert-butyl-phenyl)-2-fluoro-benzamide

Procedure

4-Bromo-N-(3-tert-butyl-phenyl)-2-fluoro-benzamide was synthesized from 3-tert-butyl-phenylamine and 4-bromo-2-fluoro-benzoic acid in a manner similar to the one described in the synthesis of 4-bromo-N-(3-tert-butyl-phenyl)-3-fluoro-benzamide above. LCMS calcd for C17H17FNO (m/e) 349, obsd 350 (M+H).

Sources & evidence

ORD record
ord-ab82b9b7ed66455fbdeb0423218edd67
Source dataset
uspto-grants-2012_12
Patent number
US08324385B2

Reaction notes

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