N-(4-tert-Butyl-phenyl)-6-piperazin-1-yl-nicotinamide → N-(3-tert-Butyl-phenyl)-6-piperazin-1-yl-nicotinamide

HRID 2190543Notes

Reaction equation

HRID 2190543 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20](=[O:32])[NH:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([CH3:31])([CH3:30])[CH3:29])[CH:23]=3)=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.C(C1C=CC(NC(=O)C2C=CC(N3CCNCC3)=NC=2)=CC=1)(C)(C)C>>[C:28]([C:24]1[CH:23]=[C:22]([NH:21][C:20](=[O:32])[C:17]2[CH:18]=[CH:19][C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)=[N:15][CH:16]=2)[CH:27]=[CH:26][CH:25]=1)([CH3:31])([CH3:29])[CH3:30]

Participants

3

Reactant 2

HCID 59318019N-(4-tert-Butyl-phenyl)-6-piperazin-1-yl-nicotinamideHCID 593181074-[5-(3-Tert-butyl-phenylcarbamoyl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 59318114N-(3-tert-Butyl-phenyl)-6-piperazin-1-yl-nicotinamide

Procedure

N-(3-tert-Butyl-phenyl)-6-piperazin-1-yl-nicotinamide was prepared from 4-[5-(3-tert-butyl-phenylcarbamoyl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester in a manner similar to the one described in the synthesis of N-(4-tert-butyl-phenyl)-6-piperazin-1-yl-nicotinamide above. HRMS m/z calcd for C20H26N4O [M+H]+: 339.2179. Found: 339.2180.

Sources & evidence

ORD record
ord-d48afe2f32d74f18b2b06a3cd186bdc4
Source dataset
uspto-grants-2012_12
Patent number
US08324385B2

Reaction notes

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