HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → N-(3-Iodo-4-methyl-phenyl)-6-piperazin-1-yl-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | N-(4-tert-Butyl-phenyl)-6-piperazin-1-yl-nicotinamide | HCID 59318019 | — |
| Reactant | 4-[5-(3-Iodo-4-methyl-phenylcarbamoyl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester | HCID 59318184 | — |
| Product | N-(3-Iodo-4-methyl-phenyl)-6-piperazin-1-yl-nicotinamide | HCID 59318071 | — |
Reaction Steps
N-(3-Iodo-4-methyl-phenyl)-6-piperazin-1-yl-nicotinamide was prepared by the TFA deprotection of 4-[5-(3-iodo-4-methyl-phenylcarbamoyl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester in a manner similar to the one described in the synthesis of N-(4-tert-butyl-phenyl)-6-piperazin-1-yl-nicotinamide above. LCMS calcd for C17H19IN4O (m/e) 422, obsd 423 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324385B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-084f4bea7c074a33b2c9b2345e1d131b |
| Source note | uspto-grants-2012_12 |