Trifluoroacetic acid → N-(3-Iodo-4-methyl-phenyl)-6-piperazin-1-yl-nicotinamide
Reaction equation
C(O)(C(F)(F)F)=O.C(OC([N:15]1[CH2:20][CH2:19][N:18]([C:21]2[CH:26]=[CH:25][C:24]([C:27](=[O:37])[NH:28][C:29]3[CH:34]=[CH:33][C:32]([CH3:35])=[C:31]([I:36])[CH:30]=3)=[CH:23][N:22]=2)[CH2:17][CH2:16]1)=O)(C)(C)C.C(C1C=CC(NC(=O)C2C=CC(N3CCNCC3)=NC=2)=CC=1)(C)(C)C>>[I:36][C:31]1[CH:30]=[C:29]([NH:28][C:27](=[O:37])[C:24]2[CH:25]=[CH:26][C:21]([N:18]3[CH2:17][CH2:16][NH:15][CH2:20][CH2:19]3)=[N:22][CH:23]=2)[CH:34]=[CH:33][C:32]=1[CH3:35]Participants
4
Procedure
N-(3-Iodo-4-methyl-phenyl)-6-piperazin-1-yl-nicotinamide was prepared by the TFA deprotection of 4-[5-(3-iodo-4-methyl-phenylcarbamoyl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester in a manner similar to the one described in the synthesis of N-(4-tert-butyl-phenyl)-6-piperazin-1-yl-nicotinamide above. LCMS calcd for C17H19IN4O (m/e) 422, obsd 423 (M+H).
Sources & evidence
- ORD record
- ord-084f4bea7c074a33b2c9b2345e1d131b
- Source dataset
- uspto-grants-2012_12
- Patent number
- US08324385B2
Reaction notes
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