HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2,3,4-Tetrahydroisoquinoline → N-(3-tert-Butyl-phenyl)-6-(3,4-dihydro-1H-isoquinolin-2-yl)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2,3,4-Tetrahydroisoquinoline | HCID 7046 | — |
| Reactant | N-(3-Iodo-4-methyl-phenyl)-6-morpholin-4-yl-nicotinamide | HCID 17541675 | — |
| Reactant | N-(3-tert-butyl-phenyl)-6-chloro-nicotinamide | HCID 59318011 | — |
| Product | N-(3-tert-Butyl-phenyl)-6-(3,4-dihydro-1H-isoquinolin-2-yl)-nicotinamide | HCID 59318014 | — |
Reaction Steps
N-(3-tert-Butyl-phenyl)-6-(3,4-dihydro-1H-isoquinolin-2-yl)-nicotinamide was synthesized from N-(3-tert-butyl-phenyl)-6-chloro-nicotinamide and 1,2,3,4-tetrahydro-isoquinoline in a method similar to the one described in the synthesis of N-(3-iodo-4-methyl-phenyl)-6-morpholin-4-yl-nicotinamide above. LCMS calcd for C25H27N3O (m/e) 385, obsd 386 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324385B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-b7562f13f58a480294e2d2e3558f2a2b |
| Source note | uspto-grants-2012_12 |