Ethyl 4-(piperazin-1-yl)benzoate → 4-{4-[5-(4-tert-Butyl-pyrimidin-2-ylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid ethyl ester

HRID 2190590Notes

Reaction equation

HRID 2190590 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][N:8]=[C:7]([NH:11][C:12](=[O:20])[C:13]2[CH:18]=[CH:17][C:16](Cl)=[N:15][CH:14]=2)[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:21]([O:23][C:24](=[O:37])[C:25]1[CH:30]=[CH:29][C:28]([N:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)=[CH:27][CH:26]=1)[CH3:22].C(OC(=O)C1C=CC(N2CCN(C3C=CC(C(=O)NC4C=CC(C)=C(I)C=4)=CN=3)CC2)=CC=1)C>CCOC(C)=O>[CH2:21]([O:23][C:24](=[O:37])[C:25]1[CH:26]=[CH:27][C:28]([N:31]2[CH2:32][CH2:33][N:34]([C:16]3[CH:17]=[CH:18][C:13]([C:12](=[O:20])[NH:11][C:7]4[N:6]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[CH:10]=[CH:9][N:8]=4)=[CH:14][N:15]=3)[CH2:35][CH2:36]2)=[CH:29][CH:30]=1)[CH3:22]

Participants

5

Reactant 3

HCID 2761178Ethyl 4-(piperazin-1-yl)benzoateHCID 59318000N-(4-tert-Butyl-pyrimidin-2-yl)-6-chloro-nicotinamideHCID 593180634-{4-[5-(3-Iodo-4-methyl-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid ethyl ester

Product 1

HCID 593181864-{4-[5-(4-tert-Butyl-pyrimidin-2-ylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid ethyl ester

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4-{4-[5-(4-tert-Butyl-pyrimidin-2-ylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid ethyl ester was prepared from N-(4-tert-butyl-pyrimidin-2-yl)-6-chloro-nicotinamide and 4-(piperazin-1-yl)-benzoic acid ethyl ester following a method similar to the one described in the synthesis of 4-{4-[5-(3-iodo-4-methyl-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid ethyl ester above. The product was isolated after silica gel column with 30-100% EtOAc in hexanes. HRMS m/z calcd for C27H32N6O3 [M+H]+: 489.2609. Found: 489.2609.

Sources & evidence

ORD record
ord-b2194aecc57f41f3994e648cc61d985d
Source dataset
uspto-grants-2012_12
Patent number
US08324385B2

Reaction notes

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