HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-tert-Butylaniline → 4-[4-(3-Tert-butyl-phenylcarbamoyl)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-tert-Butylaniline | HCID 79334 | — |
| Reactant | 4-(4-Carboxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester | HCID 22492859 | — |
| Reactant | 4-[4-(3-Tert-butyl-phenylcarbamoyl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester | HCID 59318017 | — |
| Product | 4-[4-(3-Tert-butyl-phenylcarbamoyl)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester | HCID 59318012 | — |
Reaction Steps
4-[4-(3-tert-Butyl-phenylcarbamoyl)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester was prepared from N-Boc-4-(4-carboxyphenyl)piperidine and 3-tert-butyl aniline in a manner similar to the one described in the synthesis of 4-[4-(3-tert-butyl-phenylcarbamoyl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester, above. The product was isolated after silica gel column purification with 10-50% Et2O in hexanes. HRMS m/z calcd for C26H35N3O3I [M+H]+: 437.2799. Found: 437.2796.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324385B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-1b6bd83124dd4b63bff78455220d2a14 |
| Source note | uspto-grants-2012_12 |