2,2-Dimethylsuccinic anhydride → HCID 59318075, compound

HRID 2190650Notes

Reaction equation

HRID 2190650 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([NH:11][C:12](=[O:25])[C:13]2[CH:18]=[CH:17][C:16]([CH:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)=[CH:15][CH:14]=2)[CH:8]=[CH:9][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:26][C:27]1([CH3:34])[CH2:32][C:31](=[O:33])[O:30][C:28]1=[O:29].C(C1C=C(NC(C2C=CC(N3CCN(C(=O)CC(C)(C)C(O)=O)CC3)=NC=2)=O)C=CC=1)(C)(C)C>>[C:1]([C:5]1[CH:6]=[C:7]([NH:11][C:12]([C:13]2[CH:14]=[CH:15][C:16]([CH:19]3[CH2:24][CH2:23][N:22]([C:31](=[O:33])[CH2:32][C:27]([CH3:34])([CH3:26])[C:28]([OH:30])=[O:29])[CH2:21][CH2:20]3)=[CH:17][CH:18]=2)=[O:25])[CH:8]=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 3

HCID 870672,2-Dimethylsuccinic anhydrideHCID 59317976N-(3-tert-Butyl-phenyl)-4-piperidin-4-yl-benzamideHCID 59318135HCID 59318135, compound

Product 1

HCID 59318075HCID 59318075, compound

Procedure

4-{4-[4-(3-tert-Butyl-phenylcarbamoyl)-phenyl]-piperidin-1-yl}-2,2-dimethyl-4-oxo-butyric acid was synthesized from N-(3-tert-butyl-phenyl)-4-piperidin-4-yl-benzamide and 2,2-dimethylsuccinic anhydride in a method similar to the one described in the synthesis of 4-{4-[5-(3-tert-butyl-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-2,2-dimethyl-4-oxo-butyric acid above. LCMS calcd for C28H36N2O4 (m/e) 464, obsd 465 (M+H).

Sources & evidence

ORD record
ord-121f567ff4ab48f28964adec906bc716
Source dataset
uspto-grants-2012_12
Patent number
US08324385B2

Reaction notes

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