反应详情

N-(3-tert-Butyl-phenyl)-4-{1-[3-(3-hydroxy-isoxazol-5-yl)-propionyl]-piperidin-4-yl}-benzamide was prepared by the ECDI coupling of N-(3-tert-butyl-phenyl)-4-piperidin-4-yl-benzamide and 3-(3-hydroxy-isoxazol-5-yl)-propionic acid in a manner similar to the one described in the synthesis of 4-{4-[5-(3-tert-butyl-phenylcarbamoyl)-pyridin-2-yl]-piperazine-1-carbonyl}-cyclonexanecarboxylic acid methyl ester, above. LCMS calcd for C28H33N3O4 (m/e) 475, obsd 476 (M+H).

1. customdescribed in the synthesis of 4-{4-[5-(3-tert-butyl-phenylcarbamoyl)-pyridin-2-yl]-piperazine-1-carbonyl}-cyclonexanecarboxylic acid methyl ester