Ethyl chloroformate → HCID 59318180, compound

HRID 2190670Notes

Reaction equation

HRID 2190670 reaction equation
[I:1][C:2]1[CH:3]=[C:4]([NH:9][C:10](=[O:23])[C:11]2[CH:16]=[CH:15][C:14]([N:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)=[N:13][CH:12]=2)[CH:5]=[CH:6][C:7]=1[CH3:8].[CH2:24]([O:26][C:27](Cl)=[O:28])[CH3:25].CC(C)(C)CC(N1CCN(C2C=CC(C(NC3C=CC(C)=C(I)C=3)=O)=CN=2)CC1)=O>>[CH2:24]([O:26][C:27]([N:20]1[CH2:19][CH2:18][N:17]([C:14]2[CH:15]=[CH:16][C:11]([C:10](=[O:23])[NH:9][C:4]3[CH:5]=[CH:6][C:7]([CH3:8])=[C:2]([I:1])[CH:3]=3)=[CH:12][N:13]=2)[CH2:22][CH2:21]1)=[O:28])[CH3:25]

Participants

4

Reactant 3

HCID 10928Ethyl chloroformateHCID 59318071N-(3-Iodo-4-methyl-phenyl)-6-piperazin-1-yl-nicotinamideHCID 593181756-[4-(3,3-dimethyl-butyryl)-piperazin-1-yl]-N-(3-iodo-4-methyl-phenyl)-nicotinamide

Product 1

HCID 59318180HCID 59318180, compound

Procedure

4-[5-(3-Iodo-4-methyl-phenylcarbamoyl)-pyridin-2-yl]-piperazine-1-carboxylic acid ethyl ester was synthesized from N-(3-iodo-4-methyl-phenyl)-6-piperazin-1-yl-nicotinamide and ethylchloroformate in a manner similar to the one described in the synthesis of 6-[4-(3,3-dimethyl-butyryl)-piperazin-1-yl]-N-(3-iodo-4-methyl-phenyl)-nicotinamide above. LCMS calcd for C20H23IN4O3 (m/e) 494, obsd 495 (M+H).

Sources & evidence

ORD record
ord-46b386c0ce054e449fc3023a0d7994d6
Source dataset
uspto-grants-2012_12
Patent number
US08324385B2

Reaction notes

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