HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl chloroformate → 4-[5-(3-Iodo-4-methyl-phenylcarbamoyl)-pyridin-2-yl]-piperazine-1-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | N-(3-Iodo-4-methyl-phenyl)-6-piperazin-1-yl-nicotinamide | HCID 59318071 | — |
| Reactant | 6-[4-(3,3-dimethyl-butyryl)-piperazin-1-yl]-N-(3-iodo-4-methyl-phenyl)-nicotinamide | HCID 59318175 | — |
| Product | 4-[5-(3-Iodo-4-methyl-phenylcarbamoyl)-pyridin-2-yl]-piperazine-1-carboxylic acid ethyl ester | HCID 59318180 | — |
Reaction Steps
4-[5-(3-Iodo-4-methyl-phenylcarbamoyl)-pyridin-2-yl]-piperazine-1-carboxylic acid ethyl ester was synthesized from N-(3-iodo-4-methyl-phenyl)-6-piperazin-1-yl-nicotinamide and ethylchloroformate in a manner similar to the one described in the synthesis of 6-[4-(3,3-dimethyl-butyryl)-piperazin-1-yl]-N-(3-iodo-4-methyl-phenyl)-nicotinamide above. LCMS calcd for C20H23IN4O3 (m/e) 494, obsd 495 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324385B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-46b386c0ce054e449fc3023a0d7994d6 |
| Source note | uspto-grants-2012_12 |