Hydrochloric Acid → Rx-01_423 hydrochloride

HRID 2190701Notes

Reaction equation

HRID 2190701 reaction equation
C(OC(=O)[N:7]([CH2:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[CH:23][C:22]([N:25]3[CH2:29][C@H:28]([CH2:30][NH:31][C:32](=[O:34])[CH3:33])[O:27][C:26]3=[O:35])=[CH:21][C:20]=2[F:36])=[CH:15][CH:14]=1)[CH2:8][CH2:9][CH2:10][F:11])(C)(C)C.[ClH:38]>O1CCOCC1>[ClH:38].[F:36][C:20]1[CH:21]=[C:22]([N:25]2[CH2:29][C@H:28]([CH2:30][NH:31][C:32](=[O:34])[CH3:33])[O:27][C:26]2=[O:35])[CH:23]=[CH:24][C:19]=1[C:16]1[CH:17]=[CH:18][C:13]([CH2:12][NH:7][CH2:8][CH2:9][CH2:10][F:11])=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68540787(5S)-{4'-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2'-fluoro-biphenyl-4-ylmethyl}-(3-fluoro-propyl)-carbamic acid tert-butyl ester

Product 1

HCID 11293964Rx-01_423 hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

BOC-protected amine 121 was subsequently treated with 4 N hydrogen chloride in 1,4-dioxane as in Example 1 to afford compound 11. The product obtained from this process was identical by NMR and LCMS to the material obtained in Example 1.

Sources & evidence

ORD record
ord-47bae338fac84d5cb536ba699eb9264f
Source dataset
uspto-grants-2012_12
Patent number
US08324398B2

Reaction notes

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