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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2190905Generated: October 30, 2026

4-(Trifluoromethyl)phenylboronic acid → 4-Hydroxy-2-oxo-6-(4-trifluoromethyl-phenyl)-2H-chromene-3-carboxylic acid methyl ester

https://huagongshe.com/reaction/2190905

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethyl)phenylboronic acidHCID 2734389—
Reactant6-bromo-4-hydroxy-2-oxo-2H-chromene-3-carboxylic acid methyl esterHCID 86649459—
Product4-Hydroxy-2-oxo-6-(4-trifluoromethyl-phenyl)-2H-chromene-3-carboxylic acid methyl esterHCID 86649461—

Reaction Steps

4-Hydroxy-2-oxo-6-(4-trifluoromethyl-phenyl)-2H-chromene-3-carboxylic acid methyl ester was prepared from 6-bromo-4-hydroxy-2-oxo-2H-chromene-3-carboxylic acid methyl ester and 4-(trifluoromethyl)phenylboronic acid under conditions analogous to example 3-a. MS ESI(+) m/e: 365 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08324405B2
Source datasetuspto-grants-2012_12
ORD IDord-6656c0a0d57a47d3a8afd45d3bc2a082
Source noteuspto-grants-2012_12