Sodium Glycinate → [(4-Hydroxy-2-oxo-7-phenoxy-2H-chromene-3-carbonyl)-amino]-acetic acid

Participants

Reaction Steps

A mixture of 4-hydroxy-2-oxo-7-phenoxy-2H-chromene-3-carboxylic acid ethyl ester (84 mg, 0.248 mmol) and sodium glycinate (121 mg, 1.24 mmol) in methoxyethanol (5 mL) was refluxed for 15 h; then cooled, the solvent was removed, the residue was redissolved in water, acidified with 2 M HCl, the precipitates were collected and freeze dried to give the desired title product (93 mg). ESI (m/z): 356 (M+H)+.

Provenance & Evidence