Sodium Glycinate → HCID 54746546, compound

HRID 2190912Notes

Reaction equation

HRID 2190912 reaction equation
C(O[C:4]([C:6]1[C:7](=[O:19])[O:8][C:9]2[C:14]([C:15]=1[OH:16])=[CH:13][CH:12]=[C:11]([CH3:17])[C:10]=2[CH3:18])=[O:5])C.[NH2:20][CH2:21][C:22]([O-:24])=[O:23].[Na+]>COC(O)C>[OH:16][C:15]1[C:14]2[C:9](=[C:10]([CH3:18])[C:11]([CH3:17])=[CH:12][CH:13]=2)[O:8][C:7](=[O:19])[C:6]=1[C:4]([NH:20][CH2:21][C:22]([OH:24])=[O:23])=[O:5]

Participants

4

Reactant 2

HCID 4684308Sodium GlycinateHCID 86649464HCID 86649464, compound

Product 1

HCID 54746546HCID 54746546, compoundYield 79.6%

Reagents, catalysts & solvents 1

HCID 30156371-MethoxyethanolSolvent

Procedure

A mixture of 4-hydroxy-7,8-dimethyl-2-oxo-2H-chromene-3-carboxylic acid ethyl ester (18 mg, 0.069 mmol) and sodium glycinate (34 mg, 0.34 mmol) in methoxyethanol (5 mL) was refluxed for 16 h; then cooled, the solvent was removed, the residue was redissolved in water, acidified with 2 M HCl, the precipitates were collected and freeze dried to give the desired title product (16 mg). ESI (m/z): 292 (M+H)+.

Workup

  1. temperaturewas refluxed for 16 h
  2. temperaturethen cooled
  3. customthe solvent was removed
  4. dissolutionthe residue was redissolved in water
  5. customthe precipitates were collected
  6. customfreeze dried

Sources & evidence

ORD record
ord-fd7caed8e4644e399859d655ad58d858
Source dataset
uspto-grants-2012_12
Patent number
US08324405B2

Reaction notes

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