Sodium Glycinate → HCID 54746547, compound

HRID 2190915Notes

Reaction equation

HRID 2190915 reaction equation
CO[C:3]([C:5]1[C:6](=[O:29])[O:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[C:10]([C:16]1[CH:21]=[CH:20][C:19]([O:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[CH:18][CH:17]=1)[CH:9]=2)=[O:4].[NH2:30][CH2:31][C:32]([O-:34])=[O:33].[Na+]>COC(O)C>[OH:15][C:14]1[C:13]2[C:8](=[CH:9][C:10]([C:16]3[CH:21]=[CH:20][C:19]([O:22][C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=4)=[CH:18][CH:17]=3)=[CH:11][CH:12]=2)[O:7][C:6](=[O:29])[C:5]=1[C:3]([NH:30][CH2:31][C:32]([OH:34])=[O:33])=[O:4]

Participants

4

Reactant 2

HCID 4684308Sodium GlycinateHCID 86649465HCID 86649465, compound

Product 1

HCID 54746547HCID 54746547, compoundYield 96.1%

Reagents, catalysts & solvents 1

HCID 30156371-MethoxyethanolSolvent

Procedure

A mixture of 4-hydroxy-2-oxo-7-(4-phenoxy-phenyl)-2H-chromene-3-carboxylic acid methyl ester (75 mg, 0.193 mmol) and sodium glycinate (94 mg, 0.96 mmol) in methoxyethanol (10 mL) was refluxed for 18 h; then cooled, the solvent was removed, the residue was redissolved in water, acidified with 2 M HCl, the precipitates were collected and washed with water, air dried to give the desired title product (80 mg). ESI (m/z): 432 (M+H)+.

Workup

  1. temperaturewas refluxed for 18 h
  2. temperaturethen cooled
  3. customthe solvent was removed
  4. dissolutionthe residue was redissolved in water
  5. customthe precipitates were collected
  6. washwashed with water, air
  7. customdried

Sources & evidence

ORD record
ord-1bd561e62d1b414a962e941ec4a019b1
Source dataset
uspto-grants-2012_12
Patent number
US08324405B2

Reaction notes

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