4-Fluorobenzyl bromide → HCID 67523704, compound

HRID 2190934Notes

Reaction equation

HRID 2190934 reaction equation
[OH:1][C:2]1[C:7]2[C:8](=[O:14])[O:9][C:10]([CH3:13])([CH3:12])[O:11][C:6]=2[CH:5]=[CH:4][CH:3]=1.[F:15][C:16]1[CH:23]=[CH:22][C:19]([CH2:20]Br)=[CH:18][CH:17]=1>>[F:15][C:16]1[CH:23]=[CH:22][C:19]([CH2:20][O:1][C:2]2[C:7]3[C:8](=[O:14])[O:9][C:10]([CH3:12])([CH3:13])[O:11][C:6]=3[CH:5]=[CH:4][CH:3]=2)=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 680214-Fluorobenzyl bromideHCID 110525144H-1,3-Benzodioxin-4-one, 5-hydroxy-2,2-dimethyl-

Product 1

HCID 67523704HCID 67523704, compound

Procedure

5-(4-Fluoro-benzyloxy)-2,2-dimethyl-benzo[1,3]dioxin-4-one was prepared from 5-hydroxy-2,2-dimethyl-benzo[1,3]dioxin-4-one and 4-fluorobenzyl bromide under conditions analogous to example 46-a. Crude product was purified by silica gel chromatography (eluting with 40%-100% CH2Cl2 in hexanes) to provide the title compound. MS ESI(+) m/e: 303.06 (M+1).

Workup

  1. customCrude product was purified by silica gel chromatography (eluting with 40%-100% CH2Cl2 in hexanes)

Sources & evidence

ORD record
ord-58bd2bd011b841c5a2ce9c554bc3ce3c
Source dataset
uspto-grants-2012_12
Patent number
US08324405B2

Reaction notes

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