HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzyl bromide → 5-(4-Fluoro-benzyloxy)-2,2-dimethyl-benzo[1,3]dioxin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzyl bromide | HCID 68021 | — |
| Reactant | 4H-1,3-Benzodioxin-4-one, 5-hydroxy-2,2-dimethyl- | HCID 11052514 | — |
| Product | 5-(4-Fluoro-benzyloxy)-2,2-dimethyl-benzo[1,3]dioxin-4-one | HCID 67523704 | — |
Reaction Steps
5-(4-Fluoro-benzyloxy)-2,2-dimethyl-benzo[1,3]dioxin-4-one was prepared from 5-hydroxy-2,2-dimethyl-benzo[1,3]dioxin-4-one and 4-fluorobenzyl bromide under conditions analogous to example 46-a. Crude product was purified by silica gel chromatography (eluting with 40%-100% CH2Cl2 in hexanes) to provide the title compound. MS ESI(+) m/e: 303.06 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324405B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-58bd2bd011b841c5a2ce9c554bc3ce3c |
| Source note | uspto-grants-2012_12 |