HCID 59289365, compound → HCID 68593463, compound

HRID 2191031Notes

Reaction equation

HRID 2191031 reaction equation
C([NH:9][C:10]1[N:18]=[CH:17][N:16]=[C:15]2[C:11]=1[N:12]=[CH:13][N:14]2[C@@H:19]1[O:23][C@H:22](/[CH:24]=[CH:25]/[P:26](=[O:29])([OH:28])[OH:27])[C@@H:21]([O:30]C(=O)C2C=CC=CC=2)[C@H:20]1[O:39][CH3:40])(=O)C1C=CC=CC=1>[NH4+].[OH-]>[NH2:9][C:10]1[N:18]=[CH:17][N:16]=[C:15]2[C:11]=1[N:12]=[CH:13][N:14]2[C@@H:19]1[O:23][C@H:22]([CH2:24][CH2:25][P:26](=[O:27])([OH:28])[OH:29])[C@@H:21]([OH:30])[C@H:20]1[O:39][CH3:40]

Participants

3

Reactant 1

HCID 59289365HCID 59289365, compound

Product 1

HCID 68593463HCID 68593463, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 14923Ammonium HydroxideSolvent

Procedure

Compound 21.6 (37 mg, 95% yield) was synthesized from compound 21.3 (62 mg, 0.11 mmol) by treating 21.3 with concentrated NH4OH (10 ml) at 45° C. for 30 min. 1HNMR (D2O, 300 MHz) δ 8.17 (s, 1H), 8.05 (s, 1H), 6.4 (m, 1H), 6.02-5.87 (m, 2H), 4.65(bs, 2H), 4.37 (m, 2H), 3.32(s, 3H). 31PNMR (D2O, 300 MHz) δ 11.001 ppm. LRMS (ESI) MH+ C12H16N5O6P requires 358.1. Found 358.0.

Sources & evidence

ORD record
ord-f4666679cdab4a578b925d02da5a83cf
Source dataset
uspto-grants-2012_12
Patent number
US08324179B2

Reaction notes

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