Methanol → HCID 58241680, compound

HRID 2191198Notes

Reaction equation

HRID 2191198 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4](F)[C:3]=1[I:12].[CH3:13][O-:14].[Na+].[CH3:16][OH:17]>>[I:12][C:3]1[C:4]([O:14][CH3:13])=[C:5]([N+:8]([O-:10])=[O:9])[CH:6]=[CH:7][C:2]=1[O:17][CH3:16]

Participants

4

Reactant 3

HCID 887MethanolHCID 10942334Sodium MethoxideHCID 582416821,3-difluoro-2-iodo-4-nitrobenzene

Product 1

HCID 58241680HCID 58241680, compound

Procedure

1,3-Difluoro-2-iodo-4-nitrobenzene (5.0 g, 17.5 mmol) was dissolved in 50 ml of methanol, and NaOMe (3.79 g, 70.1 mmol) was added. The solution was heated under reflux for 16 h. After concentration, the residue was chromatographed on silica gel using petroleum ether/ethyl acetate. This gave 2-iodo-1,3-dimethoxy-4-nitrobenzene (3 g) as a yellowish powder.

Workup

  1. temperatureThe solution was heated
  2. temperatureunder reflux for 16 h
  3. concentrationAfter concentration
  4. customthe residue was chromatographed on silica gel

Sources & evidence

ORD record
ord-acd36440914f4eba9771e3e77b553447
Source dataset
uspto-grants-2012_12
Patent number
US08329619B2

Reaction notes

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